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2020-10-28 NEWS RELEASE Endocyte and ITM announce Supply Agreement for No-Carrier-Added Lutetium for the Phase 3 VISION Trial West Lafayette, IN., and Munich, Germany, Feb. 26, 2018 – Endocyte, Inc. (NASDAQ Global Market: ECYT), and ITM Isotopen Technologien München AG (ITM), a specialized radiopharmaceutical company, 2021-04-09 VISION RECRUITING. Study of 177 Lu-PSMA-617 In Metastatic Castrate-Resistant Prostate Cancer (VISION) Phase III study comparing the efficacy of 177 Lu-PSMA 617 plus best standard of care versus best standard of care alone in the setting of progressive PSMA positive metastatic prostate. Radiotheranostics, injectable radiopharmaceuticals with antitumour effects, have seen rapid development over the past decade. Although some formulations are already approved for human use, more radiopharmaceuticals will enter clinical practice in the next 5 years, potentially introducing new therapeutic choices for patients.

infusion every 6 weeks for a maximum of 6 cycles) plus investigator-chosen best standard of care in the investigational arm, versus best standard of care in the control arm(1) (7) . Swiss drug major Novartis AG (NVS) announced Tuesday positive result from its phase III VISION study evaluating the efficacy and safety of radioligand therapy 177Lu-PSMA-617 in patients with advanced prostate cancer. About VISION VISION is an international, prospective, randomized, open-label, multicenter, phase III study to assess the efficacy and safety of 177 Lu-PSMA-617 (7.4 GBq administered by i.v This edition of the ESMO 2020 Vision gives an update of what has been achieved in the first two years and outlines the tangible ESMO actions that will be implemented in the years to come, up to 2020. NOT A CHANGE IN FOCUS — BUT A SHARPENING AND CLARIFYING OF THE SOCIETY’S VISION FOR ITS MEMBERS IN A FAST‑CHANGING ENVIRONMENT. I finished the LuPSMA Vision Trial in November 2019 (6 infusions).

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SE (73) VALEO VISION, Propriété Industrielle 34, rue Saint-. André, 93012 (54) PSMA-bindande medel samt användande därav.

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Lutetium-177 PSMA-617 (at a dose of 7.4 GBq administered by IV infusion every 6 weeks for a maximum of six cycles) + investigator-chosen best standard of care (Arm A) or; Investigator-chosen best standard of care alone The trial (also known as the VISION study) is nominally being sponsored by Endocyte (the developer of 177 Lu-PSMA-617), but Endocyte recently agreed to being acquired by Novartis, and so — to all practical intents and purposes — Novartis is now the effective sponsor of this trial (unless the deal falls through). The addition of the targeted radioligand therapy 177Lu-PSMA-617 to best standard of care was found to significantly improve overall survival (OS) and radiographic progression-free survival (rPFS) Background Lutetium-177 [ 177 Lu]Lu-PSMA-617 is a radiolabelled small molecule that delivers β radiation to cells expressing prostate-specific membrane antigen (PSMA), with activity and safety in patients with metastatic castration-resistant prostate cancer. VISION (NCT03511664) is a phase 3 study designed to assess the efficacy of 177 Lu-PSMA-617 in patients with PSMA-positive mCRPC. Methods: Patients were randomized 2:1 to receive best standard of care with or without 177 Lu-PSMA-617. Eligibility criteria were: PSMA expressing tumor assessed by PSMA positron emission tomography imaging; prior The VISION trial is the first international, randomized study testing the hypothesis that overall survival is increased after treatment with 177 Lu-PSMA-617 in men with advanced-stage prostate cancer. The trial also contains an alternate primary endpoint of radiographic progression-free survival whose integrity requires that patients assigned Adding the targeted radioligand therapy 177 Lu-PSMA-617 (LuPSMA) to best standard of care (BSC) improved overall survival (OS) in patients with progressive PSMA-positive metastatic castration-resistant prostate cancer (mCRPC), according to findings from the phase 3 VISION trial. 1 LuPSMA also (RTTNews) - Swiss drug major Novartis AG (NVS) announced Tuesday positive result from its phase III VISION study evaluating the efficacy and safety of radioligand therapy 177Lu-PSMA-617 in VISION is an international, prospective, randomized, open-label, multicenter, phase III study to assess the efficacy and safety of 177 Lu-PSMA-617 (7.4 GBq administered by i.v.

doi: 10.1007/s00120-020-01205-w. 177 Lu-PSMA-617 has been introduced before in this column as a PSMA-targeted radioligand therapy. 1 A Phase II Australian trial treated 30 men with metastatic castration-resistant prostate cancer who had variable lines of exposure to agents such as abiraterone, enzalutamide, docetaxel and/or cabazitaxel. 2 Seventeen (57%) patients achieved a prostate-specific antigen (PSA) decline ≥50%. One of these is a phase 3 trial called VISION (Study of 177 Lu-PSMA-617 in Metastatic Castrate-Resistant Prostate Cancer; NCT03511664). For this trial, researchers are randomly assigning 750 patients with progressive PSMA-positive metastatic castration-resistant prostate cancer to 177 Lu-PSMA-617 or best standard of care.
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2021-04-01 2020-02-16 2021-03-23 2 days ago 2021-03-23 2019-05-24 2021-03-23 2021-03-23 2020-08-26 2021-03-30 Despite the promising preliminary results of 177 Lu-PSMA-RLT, the efficacy results of VISION need to be awaited prior to using the therapy outside of compassionate use provisions. Urologe A . 2020 Jun;59(6):680-686. doi: 10.1007/s00120-020-01205-w.

1 A Phase II Australian trial treated 30 men with metastatic castration-resistant prostate cancer who had variable lines of exposure to agents such as abiraterone, enzalutamide, docetaxel and/or cabazitaxel. 2 Seventeen (57%) patients achieved a prostate-specific antigen (PSA) decline ≥50%.
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Svensk Patenttidning nr 46/2016 - PRV

with radioligand therapy 177Lu-PSMA-617 in patients with advanced prostate Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer2019Ingår i: Bispecific GRPR-antagonistic anti-PSMA/GRPR heterodimer for PET and SPECT diagnostic imaging of prostate cancer2019Ingår i: Cancers, ISSN 2072-6694, photopic and scotopic vision2020Ingår i: Vision Research, ISSN 0042-6989, E-ISSN Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA (71) Gambro Lundia AB, P.O. Box 10101, SE-220 10 LUND, SE. (74) Legal IP (73) Insite Vision Incorporated, 965 Atlantic Avenue,. Alameda LU Luxembourg. LV Latvia (74) Ström & Gulliksson AB, P.O. Box 793, SE-220 07 LUND,.

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1 The VISION trial enrolled 831 a total of men with progressive, PSMA-positive mCRPC.

In addition to these picture-only galleries, you VISION: An international, prospective, open-label, multicenter, randomized phase 3 study of 177 Lu-PSMA-617 in the treatment of patients with progressive PSMA-positive metastatic castration-resistant prostate cancer (mCRPC). Study of 177Lu-PSMA-617 In Metastatic Castrate-Resistant Prostate Cancer (VISION) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.